Vapeboss – The study, "A comparative assessment of aerosols from electronic nicotine delivery systems and cigarette smoke on endothelial cell migration: The Replica Project," replicated a previous study comparing the in vitro effects of e-cigarette vapor versus cigarette smoke.

Consistent with findings from the initial study, the research team found that aerosols from vaping products caused less cell damage than cigarette smoke. They explained that while smoke reduced endothelial wound healing ability, even at low concentrations (12.5%), vapor showed no such effect on endothelial cells even at concentrations of 80%-100%.

"In conclusion, our research further confirms the importance of EC and heated tobacco products as possible harm reduction strategies for the development of cardiovascular disease in smokers," concluded the study abstract.

Meanwhile, another study analyzing data from the Population Assessment of Tobacco & Health (PATH) study found no association between exclusive ENDS (electronic nicotine delivery systems) use and increased risk of cardiovascular disease.

Titled, "Longitudinal associations between exclusive and dual use of electronic nicotine delivery systems and cigarettes and self-reported incident diagnosed cardiovascular disease among adults," the current study analyzed waves 1-5 of the PATH Study (2013-2019). The research team looked for the risk of self-reported incident diagnosed myocardial infarction (MI; 280 incident cases) and stroke (186 incident cases) and possible associations with ENDS and/or cigarette use among adults aged 40+.

The collected data found that compared to no smoking or ENDS use, exclusive cigarette use increased the risk of MI and stroke, while exclusive ENDS use and even dual use of ENDS and cigarettes did not.

Study finds certain flavors disrupt heart's electrical conduction

On the other hand, a study in Nature Communications, titled, "E-cigarettes and their single constituents cause cardiac arrhythmias and conduction defects in mice," showed that short-term vapor exposure can disrupt heart rhythm through certain chemicals in e-liquids. For this effect, the research team concluded that the use of certain flavors or chemicals found in products can disrupt the heart's electrical conduction, causing arrhythmias.

Again, another recent study published in the journal Nicotine and Tobacco Research highlights the relative safety of smokeless tobacco products and how switching to them from combustible cigarettes is associated with a lower risk of cardiovascular disease in smokers.

Smokeless tobacco users have lower disease biomarkers

The study, "Association of Smokeless Tobacco Use With Cardiovascular Disease Risk: Insights From the Population Assessment of Tobacco and Health Study" was conducted by a research team from UCLA, UC San Francisco, Boston University, and the University of Texas at Arlington.

The researchers analyzed data from a nationally representative cohort of 4,347 adults who provided urine and blood samples in 2013–14 as part of the PATH study. Among this group, 3,034 participants used cigarettes exclusively, 338 used only smokeless tobacco, and 975 had never used any tobacco products. The collected data showed that despite similar nicotine levels, smokeless tobacco users exhibited significantly lower disease biomarkers.