Vapeboss – Recently, a study published by NIH (National Institutes of Health) found that Electronic Nicotine Delivery Systems (ENDS) cause less bronchial epithelial cell toxicity compared to conventional cigarettes.

The study, titled "Electronic nicotine delivery systems exhibit reduced bronchial epithelial cells toxicity compared to cigarette: the Replica Project", aimed to duplicate three published studies to identify and compare the cytotoxic and inflammatory effects of cigarette smoke and ENDS aerosol content in an independent multi-center ring study.

The research team established the reliability of the results and the robustness of the conclusions by replicating the author's experimental protocols, then validating them with different methods. After human bronchial epithelial cells (NCI-H292) were exposed to cigarette smoke and e-cigarette vapor, the researchers assessed the inflammatory cytokines interleukin-6 and interleukin-8, as well as the matrix remodeling mediator metalloproteinase-1.

Researchers confirmed that nearly 80% of cytotoxic effects were caused by volatile compounds in the vapor phase of smoke. They noted a reduction in the cytotoxic effects of ENDS aerosols in this regard. However, the data collected on smoke-induced inflammatory and remodeling activity showed significant differences from the original report.

Based on independent data collected from several laboratories, this study shows that the toxicity results of ENDS are significantly reduced compared to cigarettes.

Source: Vapingpost