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A recent study published in the NIH found that alternative nicotine delivery products, especially electronic nicotine delivery systems (ENDS), appear to cause less bronchial epithelial cell toxicity compared to cigarettes.

The study, titled "Electronic Nicotine Delivery Systems Show Reduced Bronchial Epithelial Cell Toxicity Compared to Cigarettes: The Replicate Project," aimed to replicate three published studies that investigated and compared the cytotoxic and inflammatory effects of cigarette smoke and ENDS aerosols, in an independent multi-center ring study.

The research team established the reliability of the results and the robustness of the conclusions by replicating the authors' experimental protocols and then also validating them through different methods. After human bronchial epithelial cells (NCI-H292) were exposed to cigarette smoke and e-cig vapor, the researchers assessed the inflammatory cytokines interleukin-6 and interleukin-8 and the remodeling mediator matrix metalloproteinase-1.

The researchers confirmed that nearly 80% of cytotoxic effects were caused by volatile compounds in the vapor phase of smoke. For these effects, they confirmed a reduction in the cytotoxic effects of ENDS aerosols. However, the data collected on inflammatory and remodeling activity triggered by smoke differed significantly from those in the original report. Considering the independent data collected from multiple laboratories, this study confirms the reduction in ENDS toxicity compared to cigarettes.

Source: Vapingpost