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The study, titled, “Changes in biomarkers after 1 increased health 80 days of tobacco heating product use: a randomized trial,” looked for biomarkers of exposure (BoE) and potential harm (BoPH) in participants, to identify any changes when smokers switch from smoking to exclusive THP use. The selected participants were healthy volunteer smokers assigned to either continue smoking or switch to THPs, and a control group of non-smoking individuals. Researchers looked for a range of BoE and BoPH associated with oxidative stress, cardiovascular and respiratory diseases, and cancer at baseline and up to 180 days.

The findings showed a decrease in biomarkers of exposure in smokers who switched to THPs compared to those who did not. “In continuous smokers, BoEs and BoPHs remained stable between baseline and day 180, while the levels of THP users of most BoEs significantly decreased, becoming similar to non-smoking controls. Also at 180 days, significant changes in many BoPHs, including total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol, 8-epi-prostaglandin F2α type III, fractional exhaled nitric oxide concentration and white blood cells counted, were directionally consistent with reduced health impact.”

Heated tobacco part of Japan’s strategy to curb smoking

Meanwhile, a recent paper by Frost & Sullivan in cooperation with tobacco company Philip Morris International (PMI) titled, “Tobacco Harm Reduction and Novel Nicotine and Tobacco Products: Evidence from the Japanese Market,” found that the introduction of HTPs has led to a 34% drop in cigarette sales.

“The commercial availability of HTPs in Japan was associated with a significant decline in conventional cigarette sales, well ahead of previous rates of decline. Moreover, even after Heated Tobacco Products became available, sales of all tobacco products (Heated Tobacco Products and conventional cigarettes) continued to decline. Despite mixed evidence, data from the 2019 National Health Survey indicate that 76% of consumers who use Heated Tobacco do so exclusively. Only 24% of HTP users maintain dual use,” said Mark Dougan, Consulting Director, Healthcare, Frost & Sullivan.

“The Japanese government differentiates HTPs from conventional cigarettes in regulations such as taxation, health warnings and indoor use restrictions, with Heated Tobacco Products generally receiving less stringent regulatory treatment than conventional cigarettes,” he added.

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